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Arriving to Prague by Train or Bus
http://www.prague-guide.co.uk/articles/9/1/Arriving-to-Prague-by-Train-or-Bus/Page1.html
By Libor Kapicka
Published on 26-Jun-07
 
All international trains arrive either at Praha hlavni nadrazi (main train station) or at Praha Holesovice. If you are arriving by bus you’re most likely to terminate your journey at the main bus terminal Praha Florenc.

All international trains arrive either at Praha hlavni nadrazi (main train station) or at Praha Holesovice.  Both are located on the C line of the subway and are served by several tram lines.
The main train station is located only a few minutes from Prague's city centre. At both stations you can find money exchange offices, tourist information offices and a left luggage service. You are also able to book accommodation through some agencies there. Train station is shame for Prague, many homeless and  people with "criminal history" hang around there.
Remember, in summer the international trains tend to be full and you should book your seat at least a few weeks ahead.

Non-stop information on train connection to Prague: tel: +420 221 111 122

If you are arriving by bus you’re most likely to terminate your journey at the main bus terminal Praha Florenc (see Florenc Map ). This bus terminal is about 15 minutes from the city centre, situated on the eastern edge of the New Town, it is easily accessible by tube (yellow line B and red line C) and trams. The bus terminal also has a left luggage facility and some exchange offices. The major railway stations may be reached from here in about 5 minutes on foot.

Non-stop Information on bus connection to Prague: tel: 900 144 444 (14czk/min)

Major railway stations:

Main (Wilson) railway station Prague 2, Wilsonova str.
(Metro station Hlavní nádraží, line C)

Prague - Holešovice Prague 7, Partyzánská
(Metro station Nádraží Holešovice, line C)

Masaryk railway station Prague 1, Hybernské
(Metro station Nam. Republiky, line B)

Smíchov railway station Prague 5, Nádražní
(Metro station Smíchovské nádraží, line B)

Generally, bus is the cheapest way to travel across Europe. The Prague has regualar connections from/to major European cities several times a week.

Coaches from UK:
Kingscourt Express: (Coach bus services between London and Prague.) www.eurobus.cz/jr/000075.html
Eurolines: (Coach services from Prague to any European city.) www.gobycoach.com
Student Agency: www.studentagency.cz
Bohemia Euroexpress International: www.bei.cz
Bohemia lines: www.bohemianlines.cz